Assessment of some Herbal Drugs for Prophylaxis of Peptic Ulcer

Abstract

Aqueous (hydrophilic) and chloroform (Lipophilic) extracts of nine medicinal plants currently used in traditional medicine, in Egypt, to treat some gastrointestinal tract (GIT) disorders were tested for their gastro-protective effect against the incidence of peptic ulcer. Indomethacin-induced ulcer in a rat model was used for this testing. Mentha microphylla, Brassica oleracea Capitata (Cabbage), B. oleracea Botrytis (cauliflower) aqueous fraction, Lagenarea sicerarea polysaccharide fraction, Oreganum marjoranum, Matricaria recutita, Solanum nigrum hydrophilic and lipophilic fractions, in addition to the chloroform fraction of Lagenarea sicerarea and Cicorium intybus afforded high protection against the incidence of gastric ulcer (~ 95%). O. syriacum hydrophilic and lipophilic fractions and gum arabic afforded moderate prophylactic effect. L. sicerarea, C. intybus hydrophilic fractions and M. microphylla lipophilic fraction were inactive. Herbs represent excellent resources for cost-effective and readily available gastro-protective remedies without side effects.