Evaluation of Analgesic Potential of Solanum trilobatum Roots

Abstract

In the present work, the antinociceptive action was assayed in several experimental models in mice: writhing, formalin and hot plate tests. The crude alkaloid fraction (25, 50, 100 mg/ ???????? ???????? ?????? ???? ?????????????????????????????? ?????????????? ?????????????????????????? ???????????????? ???????? ???????????????????????? ?????? ?????????????? ?????????? intraperitoneal injection (P < 0.001). In the formalin test, the extract (50 and 100 mg/kg) also ???????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????? ?????????????????????????????????????????????? the extract (25, 50, 100 mg/kg) when given i.p. or pentazocine (5 mg/kg, s.c.) produced a ???????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????? extract of Solanum trilobatum???????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????? peripherally.