Potential Role of the Alcohol and Smoking in the Squamous Cell Carcinoma of the Head And Neck: Review of the Current Literature and New Perspectives

Abstract

Alcohol and tobacco are responsible for a very large proportion of chronic disease and some tumors inparticular may be the result of interactions between the two risk factors. The present systematic literature reviewwas conducted to judge combined effects of alcohol drinking and tobacco, as well as and genetic polymorphismson alcohol-related cancer risk. We can conclude that the interaction of smoking and alcohol significantly increasesthe risk for aero-digestive cancers. Unfortunately, little is known about mechanisms and details of interactionwith regard to disease outcomes, which is why particular questions must be targeted in future research efforts.