Antihyperlipidaemic and antihypercholesterolaemic effects of Dorema aucheri

Abstract

Elevated serum cholesterol and triglyceride is well established as a risk factor development of arteriosclerosis and coronary heart disease. A number of clinical studies have shown that reducing elevated levels of serum cholesterol and triglyceride, by drugs or dietary intervention, could lead to reduction in the incidence of coronary-related deaths. The search for new drug with the potential to reduce or regulate serum cholesterol and triglyceride has received wide attention in recent years. Dorema aucheri is a wild species of Umbelliferous family that grows in spring season in some region of Iran and eaten as a greens by some people in south of Iran. According to this fact that some species of Umbelliferous family have antihyperlipidaemic effects, in this study we evaluated the effects of Dorema aucheri on serum cholesterol and triglyceride in rats. Serum triglyceride and total cholesterol in rats with diet-induced hyperlipidaemia were determined after oral administration of water extract of Dorema aucheri leaves. Administration of the extracts (0.5 g/ml) consecutively for 30 days reduced the triglyceride and total cholesterol level by almost 45 and 30% respectively. Our investigation confirmed that Dorema aucheri has antihyperlipidaemic property and it is an effective agent for reducing triglyceride and cholesterol in peoples with hyperlipidaemic disease.