Analgesic effect of aqueous leaf extract of Coriandrum sativum in male streptozotocin-diabetic rats

Abstract

Hyperalgesia is one of the symptoms of the diabetic neuropathy, is considered as a major clinical complaint in these patients, and could affect the quality of their living style. Since attenuation of hyperalgesia is very important, in the present study the possible analgesic effect of aqueous extract of coriander was investigated in male streptozotocin-diabetic rats using standard formalin test in both early (acute) and late (chronic) phases. In this research study, male albino Wistar rats (250-350 g) were used. They were randomly divided into three groups, i.e. control, diabetic and extract-treated diabetic. For induction of diabetes, streptozotocin (60 mg/Kg) was administered i.p. After one month, formalin test was conducted. The obtained findings demonstrated that pain sensation in the second interval (5-10 min) of the acute phase of the formalin test is higher (P