Anti-inflammatory effects of Urtica pilulifera l. seeds extracts in the rat

Abstract

Urtica pilulifera l. seeds extracts (Decocted and Methanolic extracts) have anti-inflammatory effects. In an experimental-interventional study, Anti-inflammatory effects of Urtica pilulifera l. (UPL), a Traditional Iranian Medicine (TIM) plant, were examined with formalin-induced hind paw edema model in the rat. Sodium salicylate (S.S) injection (300 mg/kg; IP) was used as a positive control group and was put to comparison with methanolic extract of UPL (20 mg/kg; IP), three doses of decocted extract of UPL (20, 40 and 80 mg/kg; IP) and a group of distilled water (6 ml/kg; IP). The differences were estimated by means of one-way ANOVA followed by LSD test for acute anti-inflammatory studies (One hour after formalin injection), and by means of Student's unpaired t-test for the chronic studies (Day one to day seven edema surveys). In Acute anti-inflammatory studies, two doses of decocted UPL extract (40 mg/kg and 80 mg/kg) and S.S group had anti-inflammatory effects (p-value