Does Endometriosis Hinder Successful Ovarian Debulking Surgery?

Abstract

Background: Endometriosis has a significant effect on many aspects of women's lives, also increasing the risk of<br />ovarian cancer. Although endometriosis is considered as a benign condition, it sometimes behaves like cancer. Methods:<br />All medical records of epithelial ovarian cancer patients during January 2011 to December 2016 were reviewed.<br />Recurrent cases were excluded. Data collected included age at diagnosis, parity, marital status, familial history of cancer,<br />menopausal status, weight, height, smoking histroy, contraception, CA 125 level, result of surgery and pathological<br />report. Results: One hundred and seventy-two medical records of patients with epithelial ovarian cancer (EOC) were<br />included. Average age at diagnosis was 52.3 years. Epithelial ovarian cancer coexisting with endometriosis (EAOC)<br />was found in nearly one-fifth of cases. Nullipara and smoking were associated with 2.3 and 8.3 fold higher risk of<br />EAOC development (aOR 2.349, 95%CI 1.012-5.451; aOR 8.26, 95%CI 1.234-55.278; respectively). Age, familial<br />history of cancer and coexistence with endometriosis were factors related to surgical outcome. More of EAOC group<br />had optimal surgery compared to the non-EAOC group (61.3% and 41.8%) with statistical significance. Conclusion:<br />Younger age, familial history of cancer and coexistence of endometriosis were factors related to optimal surgery.<br />Success of optimal surgery is greater in EAOC than in non-EAOC patients. Coexistence of endometriosis does not<br />hinder successful ovarian cancer debulking surgery.