Mean Platelet Volume and Platelet Distribution Width Are Associated with Gallbladder Cancer

Abstract

Gallbladder cancer (GBC) represents the most common biliary tract malignancy. Activated platelets play an essential<br />role in cancer development and progression. Mean platelet volume (MPV) and platelet distribution width (PDW) are<br />commonly used indexes of activated platelets in clinical practice. The aim of the current study was to investigate the<br />association of MPV and PDW with GBC. 104 GBC patients and 109 normal control subjects were entered in this<br />study between January 2015 and December 2015. We collected all participants' clinical and laboratory characteristics<br />at initial diagnosis. The odds ratios (ORs) for GBC were calculated using multivariate logistic regression analysis after<br />adjusting for confounding variables across MPV and PDW quartiles. MPV levels were markedly lower and PDW levels<br />were remarkably higher in GBC patients than control subjects. A significant correlation between PDW and lymph node<br />metastasis was detected. In addition, after adjusting for other risk factors, the ORs (95% CIs) for GBC in each MPV<br />quartile were 5.117 (1.939-13.506), 2.444 (0.917-6.516), 3.718 (1.381-10.007), and 1.000, respectively. The ORs (95%<br />CIs) for GBC in each PDW quartile were 1.000, 2.063 (0.825-5.162), 3.070 (1.108-8.507), and 12.108 (4.243-34.553),<br />respectively. In conclusion, decreased MPV and elevated PDW were independently associated with GBC. Our findings<br />suggest that MPV and PDW are available parameters for early detection of GBC.