A unique seroepidemiological pattern of HBV, HCV and HTLV-I in Nenets and Komi in Northwestern Russia

Abstract

An epidemiological study of hepatitis viruses type B (HBV) and type C (HCV) and human T-cell leukemia virus ‍type I (HTLV-I) was carried out among 105 residents (male:female=19:86) regarded as Nenets partly mixed with ‍Komi, in the region of Krasnoe, the Nenets Autonomous District of the Arkhangelsk Region, in northwestern Russia ‍in 2004. Blood was drawn from apparently healthy volunteers at ages of 41.6+16.5 (range 14-85) years. HBsAg, ‍HBsAb, HBcAb, HBeAb and HCV Ab were measured by microparticle enzyme-immunoassay, and HTLV-I Ab was ‍measured by particle agglutination. Prevalences of HBsAg(+), HBsAb(+), HBcAb(+) and HBeAb(+) were 0.0%, ‍29.5.%, 20.0% and 7.6%, respectively. The overall HBV infection rate (positive HBsAb or HBcAb) was 34.3%, ‍while no positive HCV or HTLV-I Abs could be detected. A serological subgroup with positive HBsAb and negative ‍HBcAb, consisting of 15(14.3%) females, contrasted sharply to other serological subgroups in sex, age, parent’s ‍ethnicity, positive HBeAb rate, and HBcAb inhibition%. We conclude that HBV is prevalent with unique serological ‍patterns among the Nenets, while HCV and HTLV-I infections are negligible.