Endometrial Adenocarcinoma in Young Thai Women

Abstract

<br/><b>Objective</b>: To evaluate the clinicopathological characteristics and survival analysis in endometrialadenocarcinoma women younger than the age of 40 years compare to older women. <br/><b>Methods</b>: Medical recordsof 423 endometrial adenocarcinoma patients who received primary surgical treatment at King ChulalongkornMemorial Hospital during 1996-2005 were reviewed. The patients were divided into two groups; 40 years of ageor younger (group A, 42 patients) and older than 40 years (group B, 381 patients). <br/><b>Results</b>: Up to 10% (42/423)of endometrial adenocarcinoma patients were younger than the age of 40 years. The higher incidence ofnulliparous and obesity (BMI > 30 kg/m2) was significantly demonstrated in group A (81%/34.1% and 52.4%/25.2%, respectively). However, obesity was an only independent factor in multivariate analysis. No significantdifference in surgical stage distribution and the other pathologic characteristics was demonstrated betweenboth groups. However, poor histologic grade (grade 3) and deep myometrial invasion (myometrial invasionmore than 50%) tended to be found more frequent in the patients older than the age of 40 years, although therewas no statistical significance (16% versus 4.7% and 31% versus 14.3%, respectively). Moreover, synchronousovarian cancer seemed to be higher in young patients (7.1% and 2.9%, p > .05). Median time to follow was 63months (range 0 – 145 months). Five years disease free survival and 5 years overall survival were 87.3% and92.4% in group A versus 83.8% and 88.0% in group B without statistical significance between both groups.<br/><b>Conclusions</b>: Obesity was the only independent factor associated with endometrial adenocarcinoma in youngpatients. Distribution of the surgical stage and the other pathologic characteristics were similar between bothgroups without survival benefit in young patients.