Aspirin Intake Suppresses MMC-induced Genotoxicity in Mice

Abstract

The genotoxicity induced by mitomycin C (MMC) was found to be decreased by aspirin on alkaline singlecell gel electrophoresis (SCG) assay in multiple organs of mice. Aspirin at doses of 0.5, 5 and 50 mg/kg andMMC at 2 mg/kg were administered and then liver, lung, kidney, spleen, colon and bone marrow were sampledafter 3 h. Significant protective effects of aspirin against MMC-induced genotoxicity was observed in all but thebone marrow, where no change was evident. The results suggest that the radical scavenging ability of aspirinprevents danage by MMC-induced reactive oxygen species (ROS) in multiple organs.