The role of central endogenous histamine and H1, H2 and H3 receptors on food intake in broiler chickens

Abstract

The role of endogenous histamine and H1, H2 and H3 central receptors on food intake in broiler chickenswas investigated. For this purpose, a probe was used to manipulate the concentration of endogenoushistamine by intracerebroventricular (ICV) injection of thioperamide, an H3 receptor antagonist, and R-α-methylhistamine, an H3 receptor agonist and subsequently the effects of brain histaminergic system on foodintake was assessed. Moreover, to determine the receptors involved in histamine-induced feeding behaviourchanges, H1 and H2 blockers were administered to thioperamide-treated chickens. Injection of thioperamide(600 and 300 nmol) decreased food intake dose-dependently (P