The Correlation of Blood Parameters with Size in Cases of Neoplastic Tumor

Abstract

Purpose: This study aimed to evaluate the impact of tumor volume on platelet counts (PLT) and mean platelet<br />volume (MPV) and involve these parameters on overall survival. Methods: It is a retrospective study of 99 patients with<br />lung cancer (confirmed histologically or cytologically). Sixty-six patients underwent radical operating treatment and 33<br />patients had only biopsies – due to the inoperable status of tumor According to the histopathology profile: non-small cell<br />carcinoma – 23%, adenocarcinoma - 23 %, squamous - 36%, small cell carcinoma -11%, carcinoid – 6%. The overall<br />survival was measured from the time of surgery to last observation or death. The tumor's size was established based<br />on information from histopathology protocol by using model for the ellipsoid (V=4/3 π r abc). Results: KM median<br />survival time after surgery was 20 months (95% C.I. = 16–42). The survival time depends significantly on: Tumor<br />feature, MPV (p=0.03, p=0.04). Patients with normal PLT levels have longer survival time (median: 11 months) than<br />thrombocytosis group (9.5) (p=0.6). Following both the PLT and MPV, a change-point that is equal to approximately<br />18.5 cm3 (approx. 3.3 cm in diameter) stands for a segmented relationship between tumor volume and analyzed blood<br />indicators. Conclusions: After an overstepping of the change-point of tumor volume inflammatory processes start and<br />they are associated with poor prognosis. MPV may be a valuable biomarker for the diagnosis and follow up of various<br />types of carcinoma.