Dickkopf-1 Levels in Turkish Patients with Bladder Cancer and its Association with Clinicopathological Features

Abstract

<b>Background:</b> Evidence indicates that Dickkopf-1 (DKK-1) levels may be a biomarker for cancer risk. Theaim of this study was to assess DKK-1 and its correlation with clinic-pathological features in patients withbladder cancer. Materials and <br/><b>Methods</b>: DKK-1 levels were determined in serum samples from 90 patients withbladder cancer before transurethral tumor resection. The concentrations of DKK-1 were determined by usingenzyme linked immune-sorbent assay (ELISA). <br/><b>Results</b>: Elevated preoperative DKK-1 levels were associatedwith tumor stage (p<0.001), grade (p<0.001) and histological grade (p<0.001). <br/><b>Conclusions</b>: The results of ourstudy demonstrated that the level of serum DKK-1 is correlated with both disease progression and increase inthe tumor grade. Preoperative serum DKK-1 elevation may thus represent a novel marker for the determinationof bladder cancer and the detection of patients with a likely poor clinical outcome.