Gene Polymorphism of XRCC1 Arg399Gln and Cervical Carcinoma Susceptibility in Asians: A Meta-analysis Based on 1,759 Cases and 2,497 Controls

Abstract

Many epidemiological studies in Asian populations have investigated associations between the Arg399Glngene polymorphism of X-ray repair cross complementing gene 1 (XRCC1) and risk of cervical carcinoma, butno conclusions have been available because of controversial results. Therefore a meta-analysis was conducted forclarification. Relevant studies were identified by searching the Pubmed, Embase, the Web of Science, CochraneCollaboration’s database, Chinese National Knowledge Infrastructure (CNKI), Wanfang database and ChinaBiological Medicinse (CBM) until September, 2012. A total of eight studies were included in the present metaanalysis,which described 1,759 cervical carcinoma cases and 2,497 controls. Odds ratios (ORs) and corresponding95% confidence intervals (95%CIs) as effect size were calculated by fixed-effect or random-effect models.The overall results indicated that the XRCC1-399G/A polymorphism was marginally associated with cervicalcarcinoma in Asians: OR (95%CI): 1.16 (1.07, 1.26) in the G/A vs G/G inheritance model, 1.24 (0.87, 1.76)inA/A vs G/G inheritance model, 1.13 (1.01, 1.27) in the dominant inheritance model and 1.18 (0.94, 1.47) in therecessive inheritance model. Subgroup analyses on sample size showed no significant correlation in the smallsamplesize group but the large-sample size group was consistent with the outcomes of overall meta-analysis.In the subgroup analysis by regions, we only found significant association under the G/A vs G/G inheritancemodel in the Chinese population. For the non-Chinese populations, no correlation was detected in any geneticinheritance model. In the Asian populations, XRCC1-399G/A gene polymorphism was implied to be associatedwith cervical carcinoma.