Comparisons of Curative and Side Effects of Chemoradiotherapy among Xinjiang Han, Uigur and Kazakh Esophageal Carcinoma Patients

Abstract

<br/><b>Objective</b>: This study aimed to explore the differences in the curative and side effects of chemoradiotherapyon esophageal cancer (EC) among Xinjiang Han, Uigur and Kazakh patients. <br/><b>Methods</b>: 170 patients with IIAstage-IV of esophageal squamous cell carcinoma were analyzed retrospectively. Based on different nationalities,they were divided into the Han, Uigur and Kazakh groups. The 1-, 2- and 3-year survival rates, incidence ofthe side effects (including hematological toxicities, radioactive esophagitis and percutaneous reactions) andapplication of antibiotics and harmonics were compared among the groups. There was no significant differencein the short-term curative effects among the Han, Uigur and Kazakh groups. The 1- 2- and 3-year survivalrates of the three groups were 84%, 40%, 26%; 78%, 27%, 18%; and 60%, 21%, 12% (x2=14.497, P<0.05). Theincidence rate of hamatological toxicity ≥Grade 2 in the Kazakh group was significantly lower than that in theHan or Uigur group. <br/><b>Results</b>: The incidence rates of radioactive esophagitis and percutaneous reactions Grade2 in the Han group were significantly higher than those in the Uigur or Kazakh group. There was no significantdifference in the types of applied antibiotics among the groups, but there were significant differences in the daysof antibiotic application and proportion of patients receiving harmonics between the Hans and either of othergroups. <br/><b>Conclusion</b>: Chemoradiotherapy shows a better effect in the long-term survival rate among Han ECpatients compared with Uigur or Kazakh EC patients. Uigur and Kazakh patients show a better tolerance tothe side effects of chemoradiotherapy compared with Hans.