Glutathione S-Transferase Polymorphisms in Breast Cancers of Thai Patients

Abstract

Breast cancer is the most common cancer among women worldwide and second in Thailand. Glutathione Stransferase(GST) enzymes involved in the detoxification of reactive metabolites of carcinogens may be importantin modulating susceptibility to cancers. This study aimed to determine the influence of genetic polymorphismsof glutathione S-transferase T1, M1, P1 and A1 on breast cancer in Thai patients. Links with clinico-pathologicalcharacteristics were also analyzed. The results showed no association between GSTs polymorphism and overallsusceptibility to breast cancer in Thai patients (P ≥ 0.05). However, the data pointed to a relation of theGSTP1(Ile105Val) polymorphism with progesterone receptor status (P = 0.04) and age at diagnosis (P = 0.03) ofbreast cancer cases. In summary, this is the first study to report association between glutathione S-transferaseT1, M1, P1 and A1 genes polymorphism and breast cancer in Thai patients. While GST genotypes may not beassociated with susceptibility, a GSTP1 polymorphism(Ile105Val) may be related to progression of breast cancer.