Inhibition by Vitamin E of Cholangiocarcinoma Induction due to Combined Nitrite and Aminopyrine

Abstract

The present experiment was conducted to assess the influence of vitamin E, given in the diet at 0.5 or 1%, oninduction of lesions in the Syrian hamster liver by long term combined administration of sodium nitrite andaminopyrine in the drinking water. Inhibition of both cholangiofibrosis and cholangiocarcinoma development, aswell as a reduction in hepatocellular nodules was the result. The underlying mechanisms presumably involve alterationof endogenous dimethylnitrosamine formation by the vitamin, with clear implications for prevention in the humanenvironment.