Skin Phenotype and the Impact of Surveillance on Melanoma in New Zealand

Abstract

Few studies have been performed to evaluate the effect of skin surveillance on melanoma risk. This populationbasedcase-control study was carried out to confirm the association of phenotype with melanoma and to investigatethe effect of surveillance by skin examination on the risk of melanoma in New Zealand. Cases were patients with afirst diagnosis of in-situ or invasive cutaneous malignant melanoma from three regions of New Zealand. Controlswere selected at random from the electoral rolls and frequency-matched by age. Participants included men andwomen of European origin aged between 20 and 79 years. A strong association was found between host phenotypicfactors (red hair, fair skin, many freckles on the face, and numbers of moles) and melanoma risk. These effects werelargely independent of each other.The relative risk of melanoma was significantly reduced after skin examination byone’s self, partner or a health professional; this reduction in risk remained after adjustment for phenotype, molecounts, skin reaction to sun, and exposure to sun. People who attended a ‘skin check clinic’ had a non-significantincrease in risk of melanoma.