Background: Histone deacetylase (HDAC) inhibitors have been reported to induce cell growth arrest,apoptosis and differentiation of tumor cells. The present study aimed to examine the effects of trichostatin A(TSA), ...

The inception of targeted agents has revolutionized the cancer therapy paradigm, both for physicians andpatients. A large number of molecular targeted agents for cancer therapy are currently available for clinicaluse today. ...

Background: The effect and possible mechanism of traditional Chinese medicine, baicalin, on the PI3K/Akt signaling pathway in drug-resistant human myeloid leukemia HL-60/ADR cells have been investigated inthis current ...

Aim: To evaluate the differential diagnostic potential of lesion stiffness assessed by the sonoelastographic strain index ratio (SR) and elastographic color scoring system (UE) for breast lesions. Materials and ...

Objectives: Thrombotic risk is increased in patients with cancer and there are important implications forthose who suffer a venous thromboembolism (VTE). We undertook this study to determine the frequency, ...

Cigarette smoking is one of the most important public health concerns in Korea and worldwide. Anumber of studies have been conducted to measure the health and economic burden of smoking, but thesedid not reflect recent ...

Objective: To determine the characteristics of oligoclonal bands that are frequently detected by serum proteinelectrophoresis (SPEP) and immunofixation electrophoresis (IFE) after stem cell transplantation. ...

Aims: Primary hepatocellular carcinoma (HCC) is a common malignancy often related to hepatitis viralinfection. Smad4 is known to mediate the TGF-β pathway to suppress tumorigenesis. However, the function ofSmad4 in HCC is ...

Background and objectives: Weight loss and malnutrition are common among cancer patients, these twofactors greatly affecting survival and quality of life during treatment. Since cancer is becoming increasinglycommon in the ...

Aim: To investigate the protective effect of purified fraction 1 polysaccharide extracted from Rheum tanguticumRTP1 on irradiation-induced immune damage in mice. Methods: Kunming mice were randomly divided into ...

To investigate the relationship between serum miRNA-21 (miR-21) expression in esophageal squamous cellcarcinomas (ESCCs) and its clinicopathologic features, a 1:1 matched case-control study including 21 patientswith ESCC ...

Objective: To investigate liver fibrosis, TGF-β1 levels and curative effects on hepatocellular carcinoma (HCC)with small and conventional dose perfusion chemotherapy by transcatheter arterial chemo embolization ...

Background: Breast cancer is the most common cancer among women in Malaysia. Barriers for practicingbreast self examination (BSE) await exploration. Objective: To assess the practice of BSE and its ...

Introduction: The incidence of oral premalignant and malignant lesions is on the rise due to an increasednumber of people taking in tobacco and alcohol related habits. Material and Methods: 1028 ...

Breast cancer cells undergo transformation when they spread into surrounding tissues. Studies have shownthat cancer cells undergo surface alterations and interact with the surrounding microenvironment during theinvasion ...

Gelam and Nenas monofloral honeys were investigated in this study for their chemopreventive effects againstHT 29 colon cancer cells. MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2Htetraz ...

Luteolin (LUT), a bioflavonoid has been used as a chemopreventive agent world-wide against chemicallyinduced cancer. Hence we designed an experiment to assess chemopreventive action of LUT on lipid peroxidation(LPO) and ...

Morphine is not only an analgesic treating pain for patients with cancer but also a potential anticancerdrug inhibiting tumor growth and proliferation. To gain better insight into the involvement of morphine inthe biological ...

Background & Objectives: Gastric cancer is a leading cause of cancer-related deaths in both sexes in Iran. Thisstudy was designed to assess upper GI endoscopic findings among people > 50 years targeted in a ...

Objectives: Since methylenetetrahydrofolatereductase (MTHFR) maintains the balance of circulating folate and methionine and blocks the formation of homocysteine, its regulation in relation to different cancers ...