Evaluation of 95 Cases with Mediastinal Tumors

Abstract

<strong><span style="color: black;">Introduction:</span></strong><span><span style="color: black;"><span>Mediastinum contains different vital structures that are located in the anterior and middle or posterior compartments. Various types of mediastinal masses or tumors can be seen in the mediastinum.</span></span></span><span><span style="font-family: 'Verdana','sans-serif'; color: black;"> <br /></span><strong><span style="color: black;">Materials and Methods:</span></strong></span><span><span style="color: black;"><span>This case series study was performed on 95 patients who had referred to Mashhad University of Medical Sciences between 1990 and 2010 were reviewed. The Inclusion criteria were as follows: Having primary mediastinal masses; Exact tissue pathology; Having received suitable treatment as well as having completed a 3-year follow-up after surgery; The major variables were age, sex, clinical symptoms, mass location, diagnostic procedures, imaging studies, tissue pathology, postoperative complications, mortality and a long-term survival. The patients were followed up for 3 years after the surgery.</span></span></span><span><span style="font-family: 'Verdana','sans-serif'; color: black;"> <br /></span><strong><span style="color: black;">Results:</span></strong></span><span><span><span>Ninety-five patients enrolled in the study with M/F=51/44 and the mean age of 35.4<span><span style="text-decoration: underline;">+</span></span></span><span>16.52 years. Moreover, anterior mediastinum was the compartment mostly involved in case of 66 patients with the lymphoma (n=39) as the most prevalent tumor of anterior mediastinum. Mediastinal cysts (n=10) in the middle part and neurogenic tumors (n=19) in the posterior mediastinum were the other prevalent tumors in the patients' compartments. Transthoracic Needle Biopsy was used in the diagnosis of 37 cases. Furthermore, 43 patients underwent surgery alone, 7 cases underwent surgery followed by receiving adjuvant therapy and 45 cases received adjuvant therapy alone. </span></span></span><span style="font-family: 'Verdana','sans-serif'; color: black;"><br /></span><span style="color: black;"><span>Complications emerged in 15 cases and 9 patients expired before the completion of the 3-year follow-up. Three of the mortalities happened during the patients' hospital treatment.</span></span><span><span style="font-family: 'Verdana','sans-serif'; color: black;"> <br /></span><strong><span style="color: black;">Conclusions: </span></strong></span><span><span style="color: black;"><span>In case of anterior mediastinum, pre-operation clinical diagnosis is essential while most of the posterior mediastinal tumors do not require any pre-operation clinical diagnosis. Surgery, surgery-chemoradiotherapy and chemoradiotherapy are the major methods of treatment for such tumors. For another thing, male gender was defined as a poor prognostic factor.</span></span></span> <br /><span style="font-size: 11pt; font-family: 'Verdana','sans-serif'; color: black;"> </span>