Molecular Clock and Autoimmune Diseases; An Approach to Rheumatoid Arthritis; A Review

Abstract

Circadian clock refers to a biological cycle that fluctuates in a period of ~24 hours.<br />These cycles are supported by a molecular clock and provide a temporal timerelated<br />matrix that ensures the collocation of homeostasis processes with the course<br />of environmental changes. Here in this mini-review, we are going to summarize all<br />recent finding from the last five years till date in the field of circadian and<br />evolutionary clock research in approach to rheumatoid arthritis as the world's most<br />prevalence autoimmune disease with rate of over 76 million in world population<br />and prevalence of near 0.6% of US which is almost 1.29 million people in the<br />year 2015. Rheumatoid arthritis shows a verity of symptoms besides morning<br />stiffness and increased joint pain in the early morning. This morning joint and<br />stiffness aca correlate to an elevated level of pro-inflammatory cytokines include<br />interleukin-6. The circadian clock has a regulatory role in activity and expression<br />of proteins and their gene which comes under cycle which takes part in autoimmune<br />disease expression and progression, such as fat-derived adipokines and few nuclear<br />receptors. Based on current knowledge which expanding each and every moment<br />we know the pathways that how inflammatory responses regulated base on that<br />working in a new age in the treatment of autoimmune disease especially rheumatoid<br />arthritis.