Novel synthesis of Pyrimido[4,5- e] [1,3,4] thiadiazines as potential 15- lipoxygenase inhibitors

Abstract

Treatment of 1-(5-bromo-2-chloro-6-methylpyrimidin-4-yl)-1-methylhydrazine with<br />dimethylthiocarbamoylchloride gave 7-chloro-N,N, 1,5-tetramethyl-1H-pyrimido[4,5-<br />e][1,3,4]thiadiazin-3-amine in basic acetonitrile. The latter compounds were reacted with<br />secondary amines in boiling ethanol to afford the related 7-amino derivatives.