Anti-inflammatory and antimicrobial studies of biosensitive Knoevenagel condensate β-ketoanilide Schiff base and its Co(II), Ni(II), Cu(II) and Zn(II) complexes

Abstract

A new series of transition metal complexes of Co(II), Ni(II), Cu(II) and Zn(II), has been<br />synthesized from the Knoevenagel condensate Schiff base ligand(L) derived from β-ketoanilide<br />and furfural with o-phenylenediamine and diethylmalonate. Structural features were determined<br />by spectral and analytical techniques. Square-planar geometry has been adopted by the<br />complexes except cobalt complex which has an octahedral geometry. The synthesized ligand and<br />its complexes were screened for their anti-inflammatory activity in male albino rats<br />(Carrageenan-induced rat paw oedema model). Among these complexes, copper complex shows<br />significant anti-inflammatory activity. It exhibits significant dose dependent activity in acute<br />inflammation. The doses of 100 and 200 mg kg-1 bw produced 38.3 % and 42.8 % inhibition<br />respectively after 3 h as compared with that of the standard drug (indomethacin) which showed<br />48.5 % inhibition. The in vitro antimicrobial activity of the ligand and its complexes was<br />monitored by disc diffusion method. It has been found that complexes have higher antimicrobial<br />activity than that of free ligand.