The effect of itraconazole on treatment of vaginal candidiasis

Abstract

candidiasis is one of the commonest causes of vaginitis.different treatment have been suggested for this disease.oral itraconazole is one of the newest medications.to evaluate the antifungal activity of this drug in vaginal candidiasis,this study was performed on a random sample of patients.fifty patients with vaginal candidiasis confirmed by direct examination and culture,were treated by a single doseof 400 mg of oral itraconazole.only 32 could be followed and 18 patients (36%) were omitted from the study because of attrition.complete recovery was observed in 53.1% partial recovery in 43.8% and no recovery in 3.1%.no side effects appeared and complementary laboratory examinations were normal both before and 14 days after discontinuing the treatment.taking into consideration the methodological limitations of this study,it can be concluded that the suggested single dose treatment can probably be effective in the treatment of vaginal canddidiasis.

candidiasis is one of the commonest causes of vaginitis.different treatment have been suggested for this disease.oral itraconazole is one of the newest medications.to evaluate the antifungal activity of this drug in vaginal candidiasis,this study was performed on a random sample of patients.fifty patients with vaginal candidiasis confirmed by direct examination and culture,were treated by a single doseof 400 mg of oral itraconazole.only 32 could be followed and 18 patients (36%) were omitted from the study because of attrition.complete recovery was observed in 53.1% partial recovery in 43.8% and no recovery in 3.1%.no side effects appeared and complementary laboratory examinations were normal both before and 14 days after discontinuing the treatment.taking into consideration the methodological limitations of this study,it can be concluded that the suggested single dose treatment can probably be effective in the treatment of vaginal canddidiasis.