Electrochemical determination of thiosemicarbazide using the glassy carbon electrode modified with multi-walled carbon nanotubes

Abstract

According to the advantages of electrochemical analysis like high selectivity, high sensitivity, low analyte concentration, cost-effective, portable and easy-to-use setup, this method has attracted a great amount of attention among scientists for determination of different compounds. in this work, a simple, inexpensive, and rapid electrochemical method for the determination of thiosemicarbazide (TSC) was developed by using the modified glassy carbon electrode with multi-walled carbon nanotubes (MWCNT/GCE). Cyclic voltammetry (CV) studies indicated that TSC had a sensitive irreversible oxidative peak at 0.7 V. Compared to the untreated electrode, the modified electrode showed a negative shift in the oxidation peak of TSC. Differential pulse voltammetry on MWCNT/GCE showed a linear dependence on the concentration of TSC in the range of 1 × 10^-6-100 × 10^-6 M with a limit of detection (LOD) of 0.6 × 10^-6 M. The proposed method was successfully applied to the determination of TSC in city water samples.