N,N,N',N'-Tetramethyl-N,N'-bis(sulfo)ethane-1,2- Diaminium Mesylate ‎as a Highly Effective and Dual-functional Catalyst for the Synthesis of 1-Thioamidoalkyl-2-naphthols

Abstract

<em>N,N,N',N'</em>-tetramethyl-<em>N</em>,<em>N'</em>-bis(sulfo)ethane-1,2-diaminium mesylate <strong>‎‎</strong>([TMBSED][Oms]₂) is <strong>‎</strong>used as a highly efficient and dual-functional catalyst for the one-pot multi-component <strong>‎</strong>condensation of 2-naphthol with arylaldehydes and thioacetamide under green, mild (70 °C), <strong>‎</strong>and solvent-free conditions. In this reaction, 1-thioamidoalkyl-2-naphthols are produced in <strong>‎</strong>high to excellent yields and in relatively short reaction times. In this reaction, products <strong>‎</strong>are identified by analysis of its ¹H NMR, ¹³C NMR, and FT-IR data.<strong>‎</strong> Moreover, a plausible mechanism based on dual-functionality of the catalyst was proposed.