A simulation study of calcium release channel

Abstract

The IP3R calcium release channel has been simulated using a stochastic simulation algorithm (SSA;<br />Gillespie algorithm) and De young-Keiser model. A set of different concentration for Cat' and IP3 have<br />been used. Considering the Number of molecules in each state, a non linear behavior of the system can be<br />seen clearly. The inhibiting role of the Ca+2 on the open state (X110) has been studied. The degree of<br />inhibition may depend on the IP3 concentration. Different levels of inhibition have seen in different<br />inhibited states. Using the Gillespie algorithm, the frequency graphs for each set of Ca+2 and IP3<br />concentrations and in different time domains can be achieved. The probability of open channel increases<br />with going from small time domain to large time domain. A good consistency can be inferred comparing<br />with different results from the past studies (Both in theoretical and experimental studies).A reaction pattern<br />in fast time domain has seen, too.