Preparation of Combination Tablet Containing Lisinopril (10mg)/Hydrochlorothiazide (12.5mg): Characterization and Stability studies

Abstract

In modern clinical practice, combination fixed - dose tablets have become a baseline for<br />effective therapy in many clinical conditions. The Hydrochlorothiazide (Hctz) (12.5mg) /<br />Lisinopril (Lis) (10 mg) tablet is a combination drug for treatment of hypertension. In this<br />study, the tablets were prepared by wet granulation method and characterized in terms of weight<br />variation, hardness, friability, disintegration time, dissolution and stability. A high-performance<br />liquid-chromatographic method (HPLC) was used to assay Hctz and Lis in the prepared tablets.<br />Amongst different formulations, WG14 was found to be the best for product development based<br />on both physicochemical and stability results. Pharmaceutical characteristics of the tablets were<br />compared with the Innovator tablet 1A-Pharma (Germany).