One Pot synthesis of 2-substituted benzothiazoles catalyzed by Bi2O3 nanoparticles

Abstract

A convenient and efficient synthesis of 2-substituted benzothiazole derivatives are carried out by the one-pot reaction of 2-aminothiophenol with various aromatic aldehydes in using Bi₂O₃ nanoparticles as a catalyst at 60°C. The structure of the synthesized compounds have been confirmed on the basis of by FT-IR, H1 NMR, C13 NMR, Mass spectrometry and elemental analysis. This protocol afforded advantages i.e. purification of products by non-chromatographic method. Bi₂O₃ nanoparticles is cheap, readily available, versatile, environment friendly and recyclable. The reaction has been carried out in ethanol, thus eliminating hazardous organic solvents.