Spectrophotometric first order derivative method for simultaneous determination of etoricoxib and paracetamol in tablet dosage form

Abstract

This work was aimed to develop a new, sensitive, accurate, precise, and simple UV spectrophotometric method for estimating the Etoricoxib and Paracetamol in tablet dosage form. Firstorder derivative simultaneous estimation was carried out by using the UV-visible double beam spectrophotometer. Etoricoxib and Paracetamol exhibited absorbance at working wavelength 248 nm (Zero crossing point of Paracetamol) and 258.4 nm (Zero crossing point of Etoricoxib), respectively, using methanol as a solvent. Linearity was found 1-8 μg/mL for Etoricoxib and 5.42-43.3 μg/mL for Paracetamol. Accuracy was obtained between 98.96 to 101.38% for Etoricoxib and 98.38 to 101.64% for Paracetamol. LOD an LOQ was found to be 0.122 μg/mL and 0.248 μg/mL for Etoricoxib and 0.075 μg/mL and 0.152 μg/mL for Paracetamol. The developed method was validated as per ICH Guideline. The results confirmed that the proposed method is suitable for the routine analysis for the estimation of Etoricoxib and Paracetamol in tablet dosage form.