Novel unsymmetric diimines: Synthesis and biological evaluation against pathogenic microorganisms

Abstract

<span lang="TR">In this research study, three new unsymmetric diimines (<strong>3a-3c)</strong> were prepared using a two-step process. The synthesized unsymmetric tetradentate diimines were elucidated by FT-IR, ¹H-NMR, LC-MS, elemental analysis </span><span>techniques. </span><span lang="TR">The antimicrobial and the antifungal properties of newly synthesized unsymmetrical diimines (<strong>3a-3c)</strong> and previously reported by one of us unsymmetrical diimines (<strong>4a-4c)</strong> were evaluated against<em> L. monocytogenes 4b</em>, <em>B. cereus sp.</em>, <em>S. typhi H, Br. abortus, S. epidermis sp.</em>, <em>M. Luteus sp.,</em> <em>E. coli, P. putida sp</em>. <em>Sh. dys. typ. 7 </em>ve <em>C. albicans.</em><strong> 3b</strong>, <strong>3c</strong>, <strong>4a</strong> and <strong>4c</strong> are showed the highest antimicrobial activity against <em>B.cereus sp.</em> <strong>3a</strong> and <strong>4b</strong> are exhibited the highest activity against <em>S.epidermis sp.</em> and <em>Br. abortus, </em>respectively. In addition, all unsymmetrical diimines are showed </span><span>high</span><span lang="TR"> antifungal activity against <em>C. albicans.</em></span>