Effects of lifestyle activity modification on insulin resistance and pancreatic β-cells function in obese men with insulin resistance

Abstract

<em>Introduction:</em> Pancreatic β-cells function and insulin sensitivity resistance were impaired in type 2 diabetes. The effect of lifestyle activity modification (LAM) on these parameters is unclear. The aim of present study was to examine the effect of 8 weeks LAM on pancreatic β-cells function and insulin resistance in middle aged men with insulin resistance.<br /> <em>Material & Methods: </em>Sixteen obese and overweight middle aged men (age, 35-50 years) with insulin resistance participated in this study. The subjects were randomly assigned to LAM group (n=8) or control group (n=8). The subjects in LAM group walked 2 miles in 30 minutes on a treadmill on 4 days per week for 12 weeks according to the guidelines of the Centers for Disease Control and Prevention and American College of Sports Medicine.<br /> <em>Results:</em> The results indicated that fasting blood sugar, fasting insulin and insulin resistance index decreased and pancreatic β-cells function increased significantly after the intervention.<br /> <em>Conclusion:</em> In summary, it seems that LAM improves insulin resistance and pancreatic β-cells function in obese men with insulin resistance.