A promising Stimuli-Responsive nanocomposite as a Theranostic agent for Targeted Delivery

Abstract

<strong>Introduction</strong>: A range of strategies for eliminate the cancer tissue have been used, consisting of medical operation, chemo and radiotherapy.<br /> <br /> <strong>Objective</strong>: There is a significant issue about chemotherapy, the medications targeted delivery to object tissue cells is found challengeable because of the presence of numerous physical obstructions.<br /> <br /> <strong>Materials and Methods</strong>: In the present study, we synthesized and characterized a novel and promising specific pH-stimuli-responsive tumor-targeted DDS. The synthesized magnetic nanoparticles (Nanocomposite) were fully characterized by FESEM, TEM, DLS, XRD and VSM.<br /> <br /> <strong>Results</strong>: The morphology of Nanocomposite are acquired in semi-spherical shape with the specified diameters. The Capsaicin was successfully loaded Nanocomposite represented promising and admissible biocompatibility as well as showing higher toxicity versus SK-N-MC cells in comparison with control group.<br /> <br /> <strong>Conclusion</strong>: Furthermore, uptake investigation proved that the effectively internalized Drug Delivery System (DDS). In addition, the in vitro assay represented that the synthesized Nanocomposite can act nearly fully pH stimuli-responsive and release the Capsaicin at controlled condition. MTT assay verified the higher toxicity of Capsaicin loaded into the Nanocomposite in comparison with the control group. MRI in vitro investigation demonstrated that the prepared Nanocomposite can utilized as MRI imaging agent.