Synthesis and characterization of CdO/GrO nanolayer for in vivo imaging

Abstract

<em><strong>Objective(s):</strong></em> Nanomaterials are playing major roles in imaging by delivering large imaging payloads, yie<span id="transmark" style="display: none; width: 0px; height: 0px;"></span>lding improved sensitivity. Nanoparticles have enabled significant advances in pre-clinical cancer research as drug delivery vectors. Inorganic nanoparticles such as CdO/GrO nanoparticles have novel optical properties that can be used to optimize the signal-to-background ratio. This paper reports on a novel processing route for preparation of CdO/GrO nanolayer and investigation of its optical properties for application in in vivo targeting and imaging.<br /><em><strong>Materials and Methods:</strong></em> Nanostructures were synthesized by reacting cadmium acetate and graphene powder. The effects ofdifferent parameters such as power and time of irradiation were also studied. Finally, the efficiency of CdO/GrO nanostructures as an optical composite was investigated using photoluminescence spectrum irradiation. CdO/GrO nanostructures were characterized by means of X-ray diffraction (XRD), atomic force microscopy (AFM), scanning electron microscopy (SEM), Fourier transform infrared (FT-IR) and photoluminescence (PL) spectroscopy.<br /><em><strong>Results:</strong></em> According to SEM images, it was found that sublimation temperature had significant effect on morphology and layers. The spectrum shows an emission peak at 523 nm, indicating that CdO/GrO nanolayer can be used for in vivo imaging.<br /><em><strong>Conclusion:</strong> </em>The estimated optical band gap energy is an accepted value for application in in vivo imaging using a QD–CdO/GrO nanolayer.