A Simple Access to the Synthesis of 5,6- Dihydro-4H-1,3-oxazines Under Solvent Free Condition and Microwave Irradiation

Abstract

2-Arylsubstituted 5,6-dihydro-4H-1,3-oxazines were conveniently synthesized by the condensation of 3-aminopropanol and desired carboxylic acids under solvent free and microwave conditions in short reaction times with moderate to good yields. A comparison of this method with the classical protocols using acid halides and nitrile substrates was also made.