Enhanced Cognitive and Behavioral Function as well as Neurobiochemical Enzyme Activities in Aluminum-Exposed Rats through Cerium Oxide Nanoparticles (CeO2 NPs)

Abstract

Neurological and behavioral diseases caused by toxic metals, particularly aluminum, continue to pose a substantial issue for humans. Given that aluminum is the most prevalent metal found in the earth's crust, it is inevitable to come into touch with aluminum for humans in all over the world. This work focuses on the synthesis and assessment of the therapeutic impact of cerium oxide nanoparticles (CeO2 NPs) in rats that have been exposed to aluminum. We assessed the effect of CeO2 nanoparticles on the functionality of enzymes and markers related to oxidative stress, including catalase (CAT), cholinesterase (ChE), malondialdehyde (MDA), total antioxidant capacity (TAC), monoamine oxidase (MAO), reduced glutathione (GSH), and superoxide dismutase (SOD) in the cerebral and hepatic tissues of rats subjected to aluminum exposure. Aluminum chloride was administered to the rats through subcutaneous injection at a daily dosage of 150 mg/kg for a duration of 3 weeks in order to generate oxidative stress. CeO2 nanoparticles (NPs) were administered intraperitoneally at dosages of 5 and 10 mg/kg for one week, starting from the third week. The findings demonstrated that CeO2 nanoparticles (NPs) were very successful in enhancing cognitive-behavioral patterns and increasing the activity of neurobiochemical enzymes in both liver and brain tissues. The findings indicated that CeO2 NPs might serve as a good therapeutic approach for addressing neuro-cognitive and neurobiochemical impairments caused by high levels of aluminum pollution in aluminum exposed rats model. However, it is indisputable that more investigation is necessary to evaluate the therapeutic effectiveness of CeO2 NPs on conditions caused by hazardous metal exposure.