Electrochemical Determination of Carbidopa Using Molecularly Imprinted Polymer Modified Glassy Carbon Electrode

Abstract

The molecularly imprinted polymer (MIP) sensor for the rapid and immediate detection of carbidopa (CD) has been investigated. Additionally, a voltammetric sensor based on MIP with a glassy carbon electrode (MIP/GCE) has been developed for CD detection. Under optimal conditions, we observed a strong linear correlation between the sensor's peak current and CD concentrations ranging from 1.0 to 1000.0 μM, with a low limit of detection (LOD) of 0.3 μM (S/N = 3). The modified electrode demonstrated satisfactory electrocatalytic properties for CD oxidation, allowing the sensor to selectively detect CD even in the presence of high concentrations of similar compounds. Furthermore, it was confirmed that MIP/GCE effectively detected CD in urine samples.