Volume 28, Issue 3
مرور بر اساس
ارسال های اخیر
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The mTOR pathway is involved in the process of platelet-rich plasma improving intervertebral disc degeneration
(Mashhad University of Medical Sciences, 2025-03-01)Objective(s): Platelet-rich plasma (PRP) contains multiple growth hormones that may stimulate tissue repair. We aimed to assess PRP's efficacy and explore possible mechanisms using the intervertebral disc degeneration (IDD) ...
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Cardiotoxicity caused by acrylamide in rats can be alleviated as a result of suppression of oxidative stress, endoplasmic reticulum stress, inflammation, and apoptosis by morin treatment
(Mashhad University of Medical Sciences, 2025-03-01)Objective(s): The present study investigated whether morin has a protective effect against ACR-induced cardiac toxicity.Materials and Methods: In this study, oxidative stress, inflammation, endoplasmic reticulum stress ...
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Nanomolecular silencing of TSC22D4 mRNA via a DNAsome-siRNA for enhancing insulin sensitization in hepatocytes
(Mashhad University of Medical Sciences, 2025-03-01)Objective(s): Insulin resistance (IR) is a critical component of metabolic syndrome, primarily linked to obesity. It contributes to impaired glucose metabolism, beta-cell dysfunction, and the onset of type 2 diabetes. This ...
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Comparing the effect of plasma therapy with estradiol valerate in motor and cognitive behavioral disorders in ovariectomized old rats: Behavioral, biochemical, and protein expression
(Mashhad University of Medical Sciences, 2025-03-01)Objective(s): This study investigated the effects of young plasma therapy (YPT) compared to estrogen therapy (E2T) on motor and cognitive impairments in aged ovariectomized (OVX) rats.Materials and Methods: Sixty female ...
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Scopolamine-induced memory impairment in mice: Soursop leaf extract and fractions protect the hippocampus and prefrontal cortex
(Mashhad University of Medical Sciences, 2025-03-01)Objective(s): Annona muricata" (soursop) is a medicinal plant with diverse ornamental, consumptive, and pharmacological importance. This study was designed for its anti-amnesic potential in mice. Materials and Methods: The ...
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Protective immune response induced by cationic liposomes bearing soluble antigens improves the survival of BALB/c mice against <i>Toxoplasma gondii</i> RH strain
(Mashhad University of Medical Sciences, 2025-03-01)Objective(s): An ideal strategy to control acute or chronic toxoplasmosis can be the development and production of an effective vaccine. Liposomes as immunoadjuvants may be utilized to boost immune reactions for various ...
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COTI-2 suppresses the malignancy of bladder cancer by inducing apoptosis via the AMPK-mTOR signaling pathway
(Mashhad University of Medical Sciences, 2025-03-01)Objective(s): COTI-2, an innovative oral homocysteine, has shown promising antitumor results on multiple types of cancer. However, its effects in treating bladder cancer (BCa) and the underlying molecular mechanisms have ...
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Rutin attenuates complete Freund’s adjuvant-induced inflammatory pain in rats
(Mashhad University of Medical Sciences, 2025-03-01)Objective(s): Rutin is a bioflavonoid compound renowned for its anti-oxidative, anti-inflammatory, and antinociceptive properties. The present study aims to assess its therapeutic efficacy on complete Freund's adjuvant ...
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Investigating the protective effects of fluvoxamine against sepsis-related acute lung injury through antiapoptotic, anti-inflammatory, and anti-oxidant features in rats
(Mashhad University of Medical Sciences, 2025-03-01)Objective(s): Acute lung injury (ALI) is characterized by severe hypoxia and alveolar damage, often caused by oxidative stress, endoplasmic reticulum stress (ERS), and apoptosis. Fluvoxamine (FLV), an antidepressant, has ...
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Rosmarinic acid attenuated inflammation and apoptosis in folic acid-induced renal injury: Role of FoxO3/ NFκB pathway
(Mashhad University of Medical Sciences, 2025-03-01)Objective(s): Rosmarinic acid (RA) is a herbal compound with various antioxidant and anti-inflammatory effects. This study aimed to explore the anti-inflammatory and anti-apoptotic properties of RA in folic acid-induced ...
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Synergistic effect of cold atmospheric plasma and methylene blue loaded nano micelles on treating human glioblastoma cells: An <i>in vitro</i> and molecular dynamics study
(Mashhad University of Medical Sciences, 2025-03-01)Objective(s): One of the most recent cancer treatment methods is cold atmospheric plasma (CAP), which destroys cancer cells without affecting healthy cells. Also, the created photons in the CAP flame can be used to excite ...
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Effects of pentoxifylline on mouse oocytes maturation and quality<i>in vitro</i>
(Mashhad University of Medical Sciences, 2025-03-01)Objective(s): To investigate the impact of Pentoxifylline (PTX) on the in vitro maturation (IVM) of mouse oocytes and its effect on oocyte quality.Materials and Methods: This experimental study involved culturing mouse ...
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Effect of thymoquinone on vitamin D metabolism in glucocorticoid-induced insulin resistance
(Mashhad University of Medical Sciences, 2025-03-01)Objective(s): The key ingredient in Nigella sativa, thymoquinone (TQ), has several beneficial (antioxidant and anti-inflammatory) properties. This study aimed to investigate the vitamin D metabolism in insulin resistance ...
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Role of the amygdala opioid system in the effects of stress on the post-learning sleep patterns of male Wistar rats
(Mashhad University of Medical Sciences, 2025-03-01)Objective(s): Three physiological processes interact: sleep, learning, and stress. It is essential to understand how stress affects and interacts with the link between sleep, learning, and memory since it has long been ...
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Role of bacteria in cancers and their therapeutic potential: Review of current knowledge
(Mashhad University of Medical Sciences, 2025-03-01)Cancers are extremely dynamic diseases that can actively cause refractorines to be gained from applied therapies, which is why they are at the forefront of deaths worldwide. In this literature review, we covered the most ...



