Optimization of Green Synthesis of Nickel Nanoparticles by Halomonas Elongata as Antifungal Agent

Abstract

The current study aimed to investigate the optimum conditions for the green synthesis of nickel nanoparticles (NPs) with the highest antimicrobial activity instead of the Candida albicans. To this end, nine experiments were designed using the Taguchi method, and nickel NPs were synthesized biologically using the bacterium Halomonas elongata. According to the findings, the most suitable level for nickel nitrate, incubation temperature, and incubation duration was the third level (0.7 M), the second level (32 °C) and the first level (48 h), respectively. It was calculated that the NPs under synthesis in optimum conditions inhibited more than 72% of fungal growth. Moreover, the current study examined the features of nickel NPs under synthesis by various analyses that confirmed the formation of nickel NPs with favorable structural and morphological properties. Therefore, these nanoparticles can be used in medicine and dentistry as an effective antifungal compound.