Volume 27, Issue 7
مرور بر اساس
ارسال های اخیر
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Autophagy inhibitor 3-methyladenine attenuates renal injury in streptozotocin-induced diabetic mice
(Mashhad University of Medical Sciences, 2024-07-01)Objective(s): To investigate whether 3-methyladenine (3-MA) can protect the kidney of streptozotocin (STZ) - induced diabetes mice, and explore its possible mechanism. Materials and Methods: STZ was used to induce diabetes ...
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Quality by Design approach for development and characterization of gabapentin-loaded solid lipid nanoparticles for intranasal delivery: <i>In vitro</i>, <i>ex vivo</i>, and histopathological evaluation
(Mashhad University of Medical Sciences, 2024-07-01)Objective(s): "Quality by Design" (QbD) is a novel approach to product development that involves understanding the product and process, as well as the relationship between critical quality attributes (CQA) and critical ...
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Evaluation of the influence of N-Acetylcysteine and broccoli extract on systemic paraquat poisoning: Implications for biochemical, physiological, and histopathological parameters in rats
(Mashhad University of Medical Sciences, 2024-07-01)Objective(s): Paraquat (PQ), a potent environmental herbicide, is recognized for inducing irreparable toxic damage to biological systems. This study aimed to evaluate the effectiveness of N-acetylcysteine (NAC) and broccoli ...
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Possible role of Sox11 in a rat model of surgical brain injury
(Mashhad University of Medical Sciences, 2024-07-01)Objective(s): Sox11, one of the SoxC family members, is an important transcription factor during neural development and neurogenesis. However, there is no report about its function in neural apoptosis. This research aims ...
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Crocin nano-chitosan-coated compound improves anxiety disorders, learning, and spatial memory in Alzheimer’s model induced by beta-amyloid in rats
(Mashhad University of Medical Sciences, 2024-07-01)Objective(s): Alzheimer's disease (AD) is a neurodegenerative disease that results in the gradual breakdown of brain tissue, causing the deterioration of intellectual function and ability. Crocin is a saffron carotenoid ...
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Potential antiaging activity of secretome gel of human Wharton’s jelly mesenchymal stem cells (hWJ-MSCs) in UV-induced mice models
(Mashhad University of Medical Sciences, 2024-07-01)Objective(s): Skin aging is a degenerative process that can be induced by UV irradiation. UV radiation can produce reactive oxidate stress which causes premature aging. This study aims to examine the antiaging potential ...
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N-acetylcysteine protects septic acute kidney injury by inhibiting SIRT3-mediated mitochondrial dysfunction and apoptosis
(Mashhad University of Medical Sciences, 2024-07-01)Objective(s): To investigate the protective effect of N-acetylcysteine (NAC) on septic acute kidney injury (SAKI) via regulating Sirtuin3 (SIRT3)-mediated mitochondrial dysfunction and apoptosis.Materials and Methods: By ...
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SLIT3 promotes cardiac fibrosis and differentiation of cardiac fibroblasts by RhoA/ROCK1 signaling pathway
(Mashhad University of Medical Sciences, 2024-07-01)Objective(s): Slit guidance ligand 3 (SLIT3) has been identified as a potential therapeutic regulator against fibroblast activity and fibrillary collagen production in an autocrine manner. However, this research aims to ...
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Comprehensive analysis of autophagy associated genes and immune infiltrates in cervical cancer
(Mashhad University of Medical Sciences, 2024-07-01)Objective(s): Cervical cancer (CC) is the most common gynecological malignant tumor and the fourth leading cause of cancer-related death in women. The progression of CC is significantly affected by autophagy. Our objective ...
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Royal jelly induces ROS-mediated apoptosis in acute lymphoblastic leukemia (ALL)-derived Nalm-6 cells: Shedding light on novel therapeutic approaches for ALL
(Mashhad University of Medical Sciences, 2024-07-01)Objective(s): Until recently, a conventional chemotherapy regimen for Acute lymphoblastic leukemia (ALL) is considered an efficient therapeutic method in children. However, suboptimal long-term survival rates in adults, ...
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Application of methylene blue for the prevention and treatment of COVID-19, a narrative review
(Mashhad University of Medical Sciences, 2024-07-01)The newest virus from the SARS family of viruses called acute syndrome-coronavirus-2 (SARS-CoV-2), which causes COVID-19 disease, was identified in China at the end of 2019. In March 2020, after it spread to 29 additional ...
