COMPARISON OF BRAIN CORTICAL THICKNESS IN MRI OF PATIENTS WITH EPILEPSY VERSUS CONTROL GROUP

Abstract

Introduction: Epilepsy is one of the most common neurological diseases in children and adults that often occurs as recurrent generalized tonic-clonic seizures. These seizures are associated with cardiovascular and respiratory complications that threaten survival; therefore, due to the importance of determining the rtiology of epilepsy and also to predict and prevent the occurrence of epilepsy, this study was performed to compare the thickness of the cerebral cortex in MRI of patients with epilepsy with the control group. Methods: This study was a case-control study with the participation of 31 patients with epilepsy (Case Group) and 31 non-epileptic patients referred to the radiology clinic of Imam Reza (AS) hospital in Mashhad in 1399. Initially, all patients with epilepsy between 15-59. Years were included in the study and underwent MRI. Also, according to the number of people in the kurdish group, people without epilepsy underwent MRI as a control group. After data collection, T1-Weighted and T2-Weighted images. Prepared by 1,5 tesla siemens siemens symphony MRI MRI were examined, and the thickness of temporal, peritoneal, and frontal cortex in individuals was calculated. Finally, for data analysis, the data were entered into SPSS software version 26. Results: The mean age of the case group was 36,2 11 1, 11 years, and the control group was 32,8. 11,2 years. There was no significant difference between the age and sex of the case and control groups. The findings of this study also showed that the thickness of the frontal, peritoneal and temporal cortex (both sides) of patients with epilepsy was significantly less than the control group (P <1,15). Also, changes in cortical thickness were not related to age and sex (P <1,15). Conclusion: The results of our study show the relationship between the reduced thickness of frontal, peritoneal, and temporal cortices with epilepsy; therefore, these findings provide evidence of structural changes in images due to the pathogenesis of epilepsy.