Volume 26, Issue 6
مرور بر اساس
ارسال های اخیر
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Chronic stress-induced apoptosis is mitigated by young mitochondria transplantation in the prefrontal cortex of aged rats
(Mashhad University of Medical Sciences, 2023-06-01)Objective(s): Apoptosis is common and often comorbid with aging and stress-related mood disorders. Evidence suggests that fresh mitochondria could reverse age-related dysfunctions in organs, especially in the brain. ...
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Irisin attenuates angiotensin II-induced atrial fibrillation and atrial fibrosis via LOXL2 and TGFβ1/Smad2/3 signaling pathways
(Mashhad University of Medical Sciences, 2023-06-01)Objective(s): Irisin was reported as a cardioprotective and anti-oxidative effector, while the effect on atrial fibrosis is unknown. The current research examined irisin's function in atrial fibrillation (AF); atrial ...
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Protective effect of astaxanthin and metformin in the liver of rats in which the polycystic ovary syndrome model was formed by giving letrozole
(Mashhad University of Medical Sciences, 2023-06-01)Objective(s): In this study, the effects of astaxanthin on liver tissue in rats with polycystic ovary syndrome (PCOS) were evaluated.Materials and Methods: Fifty-four Spraque-Dawley rats were divided into 9 groups: Groups: ...
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Malaysian brown macroalga<i>Padina australis</i> mitigates lipopolysaccharide-stimulated neuroinflammation in BV2 microglial cells
(Mashhad University of Medical Sciences, 2023-06-01)Objective(s): Neuroinflammation and microglial activation are pathological features in central nervous system disorders. Excess levels of reactive oxygen species (ROS) and pro-inflammatory cytokines have been implicated ...
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Amifostine inhibits acrylamide-induced hepatotoxicity by inhibiting oxidative stress and apoptosis
(Mashhad University of Medical Sciences, 2023-06-01)Objective(s): Acrylamide (ACR) is a toxic chemical agent that can induce hepatotoxicity through different mechanisms including oxidative stress and apoptosis. Amifostine is an important hepatoprotective and anti-oxidant ...
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Andrographolide alleviates paraquat-induced acute lung injury by activating the Nrf2/HO-1 pathway
(Mashhad University of Medical Sciences, 2023-06-01)Objective(s): Paraquat (PQ), a highly effective and rapidly non-selective herbicide, mainly targets the lungs and causes acute lung injury (ALI). So far, the scarcity of effective drug candidates against PQ-induced ALI ...
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Amino acid-mPEGs: Promising excipients to stabilize human growth hormone against aggregation
(Mashhad University of Medical Sciences, 2023-06-01)Objective(s): Today, the non-covalent PEGylation methods of protein pharmaceuticals attract more attention and possess several advantages over the covalent approach. In the present study, Amino Acid-mPEGs (aa-mPEGs) were ...
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Rapid detection and simultaneous identification of the <i>Mycoplasma</i> and <i>Ureaplasma</i> species by real-time PCR and melt curve analysis among fertile and infertile females
(Mashhad University of Medical Sciences, 2023-06-01)Objective(s): Mycoplasma and Ureaplasma species threaten reproductive health and fertility worldwide. Due to the lack of sensitive, accurate, and affordable diagnostic tools, the simultaneous contributions of these agents ...
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Anti-inflammatory, immunomodulatory and anti-oxidant effects of <i>Ocimum basilicum</i> L. and its main constituents: A review
(Mashhad University of Medical Sciences, 2023-06-01)Ocimum basilicum L. (O. basilicum) is an ornamental and therapeutic plant with various pharmacological effects and medical applications. In this article, detailed information on the anti-oxidant, immunomodulatory, and ...
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Regulatory NK cells in autoimmune disease
(Mashhad University of Medical Sciences, 2023-06-01)NK cells are defined as the major components of the immunological network which exerts defense against tumors and viral infections as well as regulation of innate and adaptive immunity, shaped through interaction with other ...
