Volume 25, Issue 11
مرور بر اساس
ارسال های اخیر
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Safety assessment of the <i>Quercus brantii</i> gall hydroalcoholic extract: Single and repeated oral dose toxicity studies
(Mashhad University of Medical Sciences, 2022-11-01)Objective(s): Quercus brantii galls (QBGs) are well-known in Iranian traditional medicine for treating various diseases. The aim of study was to assess the acute and repeated oral toxicity of the hydroalcoholic extract of ...
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MitoTEMPOL modulates mitophagy and histopathology of Wistar rat liver after streptozotocin injection
(Mashhad University of Medical Sciences, 2022-11-01)Objective(s): This study aims to explore the effect of mitoTEMPOL on histopathology, lipid droplet, and mitophagy gene expression of Wistar rat's liver after injection of streptozotocin (STZ).Materials and Methods: Twenty ...
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JNK and p38 gene and protein expression during liver ischemia-reperfusion in a rat model treated with silibinin
(Mashhad University of Medical Sciences, 2022-11-01)Objective(s): Signal transduction of mitogen-activated protein kinases (MAPKs) is activated during ischemia. In this study, c-Jun N-terminal Kinase (JNK) and p38 MAPK (p38) gene and protein expression were evaluated as two ...
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The effects of betulinic acid chronic administration on the motor, non-motor behaviors, and globus pallidus local field potential power in a rat model of hemiparkinsonism
(Mashhad University of Medical Sciences, 2022-11-01)Objective(s): Parkinson's disease (PD) is a neurodegenerative disorder involving the central nervous system associated with motor and non-motor impairments. Betulinic acid (BA) is a natural substance considered an antioxidative ...
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<i>Rhus coriaria</i> extracts inhibit quorum sensing related virulence and biofilm production in drug-resistant <i>Pseudomonas aeruginosa</i> recovered from burn wounds
(Mashhad University of Medical Sciences, 2022-11-01)Objective(s): Numerous studies have confirmed sumac's ability to inhibit pathogens and even eradicate chronic drug-resistant infections. Current research was conducted to demonstrate the action of various sumac extracts ...
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TLR4‐IN‐C34 protects against acute kidney injury via modulating TLR4/MyD88/NF-κb axis, MAPK, and apoptosis
(Mashhad University of Medical Sciences, 2022-11-01)Objective(s): Acute kidney injury (AKI) is a major component of isoproterenol (ISO) induced cardiorenal syndrome. In this study, we investigated the effect of TLR4‐IN‐C34 as a toll-like receptor (TLR)-4 inhibitor on ...
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PPD in HBsAg vaccine formulation suppressed IFN-γ and IL-4 cytokine responses and induced long-lived humoral immune responses: Results from 220-day monitoring of specific IgG responses
(Mashhad University of Medical Sciences, 2022-11-01)Objective(s): HBsAg vaccine is unable to induce Th1 immune responses. Here, immune responses and long-lived IgG responses of HBsAg-Alum, HBsAg-MF59, as well as HBsAg-MF59 were compared when formulated with PPD. Materials ...
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Isoflavone daidzein ameliorates renal dysfunction and fibrosis in a postmenopausal rat model: Intermediation of angiotensin AT1 and Mas receptors and microRNAs 33a and 27a
(Mashhad University of Medical Sciences, 2022-11-01)Objective(s): Chronic kidney disease (CKD), accompanied by renal dysfunction, fibrosis, and apoptosis, is highly prevalent in postmenopausal women. We tested the hypothesis that isoflavone daidzein may ameliorate renal ...
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<i>In silico</i> analysis of the substitution mutations and evolutionary trends of the SARS-CoV-2 structural proteins in Asia
(Mashhad University of Medical Sciences, 2022-11-01)Objective(s): To address a highly mutable pathogen, mutations must be evaluated. SARS-CoV-2 involves changing infectivity, mortality, and treatment and vaccination susceptibility resulting from mutations.Materials and ...
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Metabolite profiling and nephroprotective potential of <i>Glycyrrhiza glabra</i> L. roots against cisplatin-induced nephrotoxicity <i>in vitro</i> and <i>in vivo</i>
(Mashhad University of Medical Sciences, 2022-11-01)Objective(s): The present study was conducted to investigate the phytochemical analysis and demonstrate the nephroprotective potential of root extract of Glycyrrhiza glabra L. against cisplatin (CP) -induced nephrotoxicity ...
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Effects of <i>Portulaca oleracea</i> L. (purslane) on the metabolic syndrome: A review
(Mashhad University of Medical Sciences, 2022-11-01)Metabolic syndrome (MetS) is defined as a disorder with multiple abnormalities, including obesity, high blood pressure, dyslipidemia, and high blood glucose. MetS is the best-known risk factor for type 2 diabetes mellitus ...
