Cervical Cancer Detection between Conventional and Liquid Based Cervical Cytology: a 6-Year Experience in Northern Bangkok Thailand

Abstract

Objectives: To determine the prevalence of abnormal Papanicolaou (Pap) smear, cervical intraepithelial neoplasia<br />(CIN) 2 or higher and cancer between conventional Pap smear (CPP) and liquid based Pap smear (LBP). Methods: This<br />retrospective study was conducted at Bhumibol Adulyadej Hospital, Bangkok, Thailand between January 2011 and<br />December 2016. Data was collected from medical records of participants who attended for cervical cancer screening test.<br />Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy for detecting<br />CIN 2 or higher were evaluated by using the most severity of histopathology reports. Results: A total of 28,564 cases<br />were recruited. Prevalence of abnormal Pap smear from CPP and LBP were 4.8 % (1,092/22,552) and 5.7 % (345/6,012),<br />respectively. Percentage of unsatisfactory smears in CPP (52.3%) was higher than LBP (40.5%). From CPP and LBP,<br />cervical cancer percentages were 0.2 and 0.1, respectively. Sensitivity, specificity, PPV, NPV and accuracy of CPP and<br />LBP for detection cancer were 42.5 vs 26.1%, 99.9 vs 100.0%, 69.8vs 75.0%, 99.7 vs 100.0 % and 99.7 vs 99.7%,<br />respectively. Conclusion: Prevalence of abnormal cervical cytology and cancer from CPP and LBP were 4.8/0.2<br />and 5.7/0.1 percent, respectively. Unsatisfactory smear of LBP was less than CPP. Sensitivity, specificity, PPV, NPV<br />and accuracy of CPP and LBP for detection CIN 2 or higher and cancer were comparable.