نمایش مختصر رکورد

Radioprotective effect of thymol against salivary glands dysfunction induced by ionizing radiation in rats

dc.contributor.authorHoseinimehr, Seyed Jalalen_US
dc.contributor.authorAbedi, Seyed Mohammaden_US
dc.contributor.authorYarmand, Fatemeen_US
dc.date.accessioned1399-07-09T06:58:36Zfa_IR
dc.date.accessioned2020-09-30T06:58:36Z
dc.date.available1399-07-09T06:58:36Zfa_IR
dc.date.available2020-09-30T06:58:36Z
dc.date.issued2016-11-01en_US
dc.date.issued1395-08-11fa_IR
dc.date.submitted2014-12-01en_US
dc.date.submitted1393-09-10fa_IR
dc.identifier.citationHoseinimehr, Seyed Jalal, Abedi, Seyed Mohammad, Yarmand, Fateme. (2016). Radioprotective effect of thymol against salivary glands dysfunction induced by ionizing radiation in rats. Iranian Journal of Pharmaceutical Research, 15(4), 861-866. doi: 10.22037/ijpr.2016.1908en_US
dc.identifier.issn1735-0328
dc.identifier.issn1726-6890
dc.identifier.urihttps://dx.doi.org/10.22037/ijpr.2016.1908
dc.identifier.urihttp://ijpr.sbmu.ac.ir/article_1908.html
dc.identifier.urihttps://iranjournals.nlai.ir/handle/123456789/313104
dc.description.abstractThe aim of this study was to investigate the radioprotective effect of thymol as a natural product against salivary glands dysfunction induced by ionizing radiation in rats. The rats were treated with thymol at dose of 50 mg/Kg before exposure to radiation at dose 15Gy. Salivary gland function was evaluated with radioisotope scintigraphy and then salivary gland to background counts ratio was calculated. Ionizing radiation caused significant salivary glands dysfunction at the 3th and the 70th days with reduction in radioactivity uptake in salivary glands. Ratios of salivary gland to background radioactivities were 2.0±0.05, 1.58±0.62 and 1.99±0.07 at 3th days for control, radiation, and thymol plus radiation groups, respectively. Thymol significantly protected acute and chronic salivary gland dysfunction induced by ionizing radiation in the rats. This finding may have been a promising application of thymol for the protection of salivary glands dysfunction induced by ionizing irradiation in patients exposed to radiation in head and neck cancer therapyen_US
dc.format.extent595
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoen_US
dc.publisherSchool of Pharmacy, Shahid Beheshti University of Medical Sciencesen_US
dc.relation.ispartofIranian Journal of Pharmaceutical Researchen_US
dc.relation.isversionofhttps://dx.doi.org/10.22037/ijpr.2016.1908
dc.subjectThymolen_US
dc.subjectradioprotectiveen_US
dc.subjectsalivary gland dysfunctionen_US
dc.subjectscintigraphyen_US
dc.subjectRadiotherapyen_US
dc.subjecttoxicology and Pharmacologyen_US
dc.titleRadioprotective effect of thymol against salivary glands dysfunction induced by ionizing radiation in ratsen_US
dc.typeTexten_US
dc.typeResearch articleen_US
dc.contributor.departmentFaculty of Pharmacy, Mazandaran University of Medical Sciencesen_US
dc.contributor.departmentDepartment of Radiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iranen_US
dc.contributor.departmentDepartment of Oral Medicine, Faculty of Dentistry, Babol University of Medical Science, Babol, Iranen_US
dc.citation.volume15
dc.citation.issue4
dc.citation.spage861
dc.citation.epage866
nlai.contributor.orcid0000-0001-8055-8036


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