نمایش مختصر رکورد

dc.contributor.authorRezaei, Men_US
dc.contributor.authorRezvani, Nen_US
dc.contributor.authorAhmadiani, Aen_US
dc.date.accessioned1399-07-09T06:56:36Zfa_IR
dc.date.accessioned2020-09-30T06:56:36Z
dc.date.available1399-07-09T06:56:36Zfa_IR
dc.date.available2020-09-30T06:56:36Z
dc.date.issued2006-07-01en_US
dc.date.issued1385-04-10fa_IR
dc.date.submitted2010-11-20en_US
dc.date.submitted1389-08-29fa_IR
dc.identifier.citationRezaei, M, Rezvani, N, Ahmadiani, A. (2006). Impact of Duration and Severity of Persistent Pain on Programmed Cell Death. Iranian Journal of Pharmaceutical Research, 5(3), 203-208. doi: 10.22037/ijpr.2010.676en_US
dc.identifier.issn1735-0328
dc.identifier.issn1726-6890
dc.identifier.urihttps://dx.doi.org/10.22037/ijpr.2010.676
dc.identifier.urihttp://ijpr.sbmu.ac.ir/article_676.html
dc.identifier.urihttps://iranjournals.nlai.ir/handle/123456789/312465
dc.description.abstractProgrammed cell death is a highly regulated form of cell death, mostly distinguished by the activation of a family of cystein-aspartate proteases (caspases) that cleave various proteins resulting in morphological and biochemical changes characteristic of this form of cell death. Several recent studies have addressed the role of programmed cell death in inflammatory and chronic pain states. Caspase-3 plays a central role in mediating nuclear programmed cell death including chromatin condensation and DNA fragmentation as well as cell blebbing. The aims of this study were to investigate the effect of duration and severity of persistent pain on the induction of programmed cell death. Formalin was administered subcutaneously in the Wistar rat hind paws for 1, 4 or 7 consecutive days, and then the activity of caspase-3 was measured in both the rat liver and brain cells. Morphological changes characterizing programmed cell death were also studied using the Sigma’s Apoptosis Detection kit, Annexin V-Cy3. Our findings showed that caspase-3 activity and apoptotic phenotype significantly increased in liver but not brain cells following the increase in duration and severity of formalin induced persistent pain.en_US
dc.format.extent1287
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoen_US
dc.publisherSchool of Pharmacy, Shahid Beheshti University of Medical Sciencesen_US
dc.relation.ispartofIranian Journal of Pharmaceutical Researchen_US
dc.relation.isversionofhttps://dx.doi.org/10.22037/ijpr.2010.676
dc.subjectInflammatory painen_US
dc.subjectReactive oxygen speciesen_US
dc.subjectCaspase, programmed cell deathen_US
dc.subjectGliaen_US
dc.subjectHepatocytesen_US
dc.subjectRaten_US
dc.titleImpact of Duration and Severity of Persistent Pain on Programmed Cell Deathen_US
dc.typeTexten_US
dc.citation.volume5
dc.citation.issue3
dc.citation.spage203
dc.citation.epage208


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