Volume 13, KKSuppl
مرور بر اساس
ارسال های اخیر
-
Evaluation of Postoperative Adjuvant Chemotherapy for Intrahepatic Cholangiocarcinoma Patients undergoing R1 and R2 Resections
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Surgical resection is the gold standard treatment and is considered the only potential cure for cholangiocarcinoma(CCA). However, most of the patients present at a late stage of disease and positive margins are ...
-
Evaluation of Efficacy, Safety and Tolerability of High Dose-Intermittent Calcitriol Supplementation to Advanced Intrahepatic Cholangiocarcinoma Patients - A Pilot Study
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Antitumor activity (growth suppression) of vitamin D has been demonstrated using cholangiocarcinoma(CCA) cell lines, CCA cell-grafted animal models, and human CCA tissue cultures. The present study aimed todetermine the ...
-
Cepharanthine Suppresses Metastatic Potential of Human Cholangiocarcinoma Cell Lines
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Cholangiocarcinoma (CCA) is a highly metastatic tumor with poor responses to traditional chemotherapeuticagents. We have focused on new drugs which can exert effects either alone or in combination with available agentsfor ...
-
Suppression of PRKAR1A Expression Enhances Antiproliferative and Apoptotic Effects of Protein Kinase Inhibitors and Chemotherapeutic Drugs on Cholangiocarcinoma Cells
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Suppression of protein kinase A regulatory subunit 1 alpha (PRKAR1A) has been proven to inhibitcholangiocarcinoma (CCA) cell growth and enhance apoptosis. In the present study, we aimed to determinesynergistic and/or ...
-
Possible Involvement of Cyclophilin A Processing in Fumagillin-Induced Suppression of Cholangiocarcinoma Cell Proliferation
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Methionine aminopeptidase 2 (MetAP2), a proteolytic enzyme that removes the N-terminal methioninefrom newly synthesized cellular proteins, plays roles in the development of various cancers and has been foundto be over-expressed ...
-
NQO1 Expression Correlates with Cholangiocarcinoma Prognosis
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Cholangiocarcinoma (CCA) is a rare type of liver cancer with a very poor prognosis. The prevalence of CCAis markedly variable with the highest incidence in the northeast Thailand, followed by other parts of SoutheastAsia ...
-
TNP-470, A Methionine Aminopeptidase-2 Inhibitor, Inhibits Cell Proliferation, Migration and Invasion of Human Cholangiocarcinoma Cells In Vitro
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Methionine aminopeptidase-2 (MetAP2) is over-expressed in several cancers, including the cholangiocarcinoma(CCA). We reported previously suppressive effects of fumagillin, a MetAP2 inhibitor, on growth of CCA cell lines.In ...
-
Overexpression of O-GlcNAc-Transferase Associates with Aggressiveness of Mass-Forming Cholangiocarcinoma
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)O-GlcNAcylation, an important O-linked glycosylation of cellular glycoproteins with a single molecule ofN-acetylglucosamine (GlcNAc), is involved in regulation of many cellular processes. Alteration of O-GlcNAcylationis ...
-
Cytokines Released from Activated Human Macrophages Induce Epithelial Mesenchymal Transition Markers of Cholangiocarcinoma Cells
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Stromal-epithelial interactions are important for carcinogenesis. Once cancerous lesions develop, a chronicallyinflamed tumor microenvironment promotes migration and invasion of tumor cells. Multiple immune cellpopulations ...
-
Aberrant Glycosylation in Cholangiocarcinoma Demonstrated by Lectin-histochemistry
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Cholangiocarcinoma (CCA) is an aggressive malignant tumor which is difficult to diagnose at an early stage.Because no reliable CCA specific markers are available at present, most patients are diagnosed after late ...
-
Aberrant Expression of CD44 in Bile Duct Cancer Correlates with Poor Prognosis
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)CCD44, a transmembrane glycoprotein receptor, plays significant roles in cell migration, differentiation, andsurvival signaling which are important for both normal and cancer cells. In this study, we examined the expressionof ...
-
High Expression of ABCC1 Indicates Poor Prognosis in Intrahepatic Cholangiocarcinoma
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Intrahepatic cholangiocarcinoma (ICC) is a serious health problem in Thailand. To reach a cure, radicalresection is the gold standard but most patients are not candidates because of delayed first presentation.Palliative ...
-
Serum Adhesion Molecule-1 (ICAM-1) as a Potential Prognostic Marker for Cholangiocarcinoma Patients
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Cholangiocarcinoma (CCA) is a malignancy of bile ducts with a high incidence of invasion and metastasis.This disease is often detected in advanced stages because of the difficulties of early diagnosis, leading to a ...
-
Impaired Antioxidant Enzyme Activity and Increased DNA Repair Enzyme Expression in Hamster Liver Tissues Related to Cholangiocarcinoma Development
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)A possible mechanism of liver fluke (Opisthorchis viverrini; Ov) -associated cholangiocarcinoma (CCA) genesismay be imbalance in responses of antioxidant enzymes and/or DNA repair enzymes which are the consequenceof ...
-
Expression Profiles of Oncomir miR-21 and Tumor Suppressor let-7a in the Progression of Opisthorchiasis-Associated Cholangiocarcinoma
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Altered miRNA expression could be a determinant of cancer development and/or progression. We aimedto study the role of oncomir miR-21 and tumor suppressor let-7a in the genesis of Opisthorchiasis-associatedcholangiocarcinoma ...
-
Identification of Biliary Bile Acids in Patients with Benign Biliary Diseases, Hepatocellular Carcinoma and Cholangiocarcinoma
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Bile acids are implicated as aetiological factors in many types of gastrointestinal tract cancer includingcholangiocarcinoma (CCA). Alterations in bile acid concentrations may affect the pathogenesis of these differenttypes ...
-
Serial Analysis of Gene Expression Reveals Promising Therapeutic Targets for Liver Fluke-associated Cholangiocarcinoma
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Cholangiocarcinoma (CCA) continues to be a serious health problem and is the most common fatalcancer in northeastern Thailand. Comprehensive gene expression analysis was here used to identify possibletherapeutic targets ...
-
Hypoxia Enhances Aggressiveness of Cholangiocarcinoma Cells
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Hypoxia, a common feature of solid tumors, plays a significant role in determining tumor phenotype andtumor progression. In this study, using an in-house PCR-array, we investigated phenotypic changes anddifferentially ...
-
Overexpression of Claudin-4 in Cholangiocarcinoma Tissues and its Possible Role in Tumor Metastasis
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Claudin-4 (CLDN4) is a tight junction protein that forms apical junctional complexes in epithelial andendothelial cellular sheets. Acting as a barrier and control of permeability are the general functions of tightjunction ...
-
Viral Hepatitis B, C Infection and Genotype Distributionamong Cholangiocarcinoma Patients in Northeast Thailand
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)The prevalence of HBV and HCV infection among 295 cholangiocarcinoma (CCA) patients in northeast Thailand was analyzed. Hepatitis B surface antigen (HBsAg) was detected in 8.8% (26/295 cases) and antibodies to HCV (anti-HCV) ...
