Volume 13, KKSuppl
مرور بر اساس
ارسال های اخیر
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Suppression of PRKAR1A Expression Enhances Antiproliferative and Apoptotic Effects of Protein Kinase Inhibitors and Chemotherapeutic Drugs on Cholangiocarcinoma Cells
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Suppression of protein kinase A regulatory subunit 1 alpha (PRKAR1A) has been proven to inhibitcholangiocarcinoma (CCA) cell growth and enhance apoptosis. In the present study, we aimed to determinesynergistic and/or ...
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Possible Involvement of Cyclophilin A Processing in Fumagillin-Induced Suppression of Cholangiocarcinoma Cell Proliferation
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Methionine aminopeptidase 2 (MetAP2), a proteolytic enzyme that removes the N-terminal methioninefrom newly synthesized cellular proteins, plays roles in the development of various cancers and has been foundto be over-expressed ...
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Evaluation of Efficacy, Safety and Tolerability of High Dose-Intermittent Calcitriol Supplementation to Advanced Intrahepatic Cholangiocarcinoma Patients - A Pilot Study
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Antitumor activity (growth suppression) of vitamin D has been demonstrated using cholangiocarcinoma(CCA) cell lines, CCA cell-grafted animal models, and human CCA tissue cultures. The present study aimed todetermine the ...
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Evaluation of Postoperative Adjuvant Chemotherapy for Intrahepatic Cholangiocarcinoma Patients undergoing R1 and R2 Resections
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Surgical resection is the gold standard treatment and is considered the only potential cure for cholangiocarcinoma(CCA). However, most of the patients present at a late stage of disease and positive margins are ...
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Cepharanthine Suppresses Metastatic Potential of Human Cholangiocarcinoma Cell Lines
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Cholangiocarcinoma (CCA) is a highly metastatic tumor with poor responses to traditional chemotherapeuticagents. We have focused on new drugs which can exert effects either alone or in combination with available agentsfor ...
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Overexpression of O-GlcNAc-Transferase Associates with Aggressiveness of Mass-Forming Cholangiocarcinoma
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)O-GlcNAcylation, an important O-linked glycosylation of cellular glycoproteins with a single molecule ofN-acetylglucosamine (GlcNAc), is involved in regulation of many cellular processes. Alteration of O-GlcNAcylationis ...
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Aberrant Expression of CD44 in Bile Duct Cancer Correlates with Poor Prognosis
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)CCD44, a transmembrane glycoprotein receptor, plays significant roles in cell migration, differentiation, andsurvival signaling which are important for both normal and cancer cells. In this study, we examined the expressionof ...
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Aberrant Glycosylation in Cholangiocarcinoma Demonstrated by Lectin-histochemistry
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Cholangiocarcinoma (CCA) is an aggressive malignant tumor which is difficult to diagnose at an early stage.Because no reliable CCA specific markers are available at present, most patients are diagnosed after late ...
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Identification of Biliary Bile Acids in Patients with Benign Biliary Diseases, Hepatocellular Carcinoma and Cholangiocarcinoma
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Bile acids are implicated as aetiological factors in many types of gastrointestinal tract cancer includingcholangiocarcinoma (CCA). Alterations in bile acid concentrations may affect the pathogenesis of these differenttypes ...
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Serial Analysis of Gene Expression Reveals Promising Therapeutic Targets for Liver Fluke-associated Cholangiocarcinoma
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Cholangiocarcinoma (CCA) continues to be a serious health problem and is the most common fatalcancer in northeastern Thailand. Comprehensive gene expression analysis was here used to identify possibletherapeutic targets ...
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Viral Hepatitis B, C Infection and Genotype Distributionamong Cholangiocarcinoma Patients in Northeast Thailand
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)The prevalence of HBV and HCV infection among 295 cholangiocarcinoma (CCA) patients in northeast Thailand was analyzed. Hepatitis B surface antigen (HBsAg) was detected in 8.8% (26/295 cases) and antibodies to HCV (anti-HCV) ...
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Impaired Antioxidant Enzyme Activity and Increased DNA Repair Enzyme Expression in Hamster Liver Tissues Related to Cholangiocarcinoma Development
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)A possible mechanism of liver fluke (Opisthorchis viverrini; Ov) -associated cholangiocarcinoma (CCA) genesismay be imbalance in responses of antioxidant enzymes and/or DNA repair enzymes which are the consequenceof ...
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Expression Profiles of Oncomir miR-21 and Tumor Suppressor let-7a in the Progression of Opisthorchiasis-Associated Cholangiocarcinoma
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Altered miRNA expression could be a determinant of cancer development and/or progression. We aimedto study the role of oncomir miR-21 and tumor suppressor let-7a in the genesis of Opisthorchiasis-associatedcholangiocarcinoma ...
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State of Serum Markers for Detection of Cholangiocarcinoma
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Difficulties in cholangiocarcinoma (CCA) management are largely due to the lack of specific biomarkers todiagnose CCA patients at an early stage. Most of CCA patients are diagnosed when the tumors have alreadyextensively ...
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Anti-inflammatory Agents Suppress the Prostaglandin E2 Production and Migration Ability of Cholangiocarcinoma Cell Lines
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Prostaglandin E2 (PGE2), one of the products catalyzed by cyclooxygenases (COXs), could actuate severalpathways implicated in chronic inflammation-related cancer, including apoptosis evasion, cell proliferation,migration ...
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Genetic Polymorphism of Drug Metabolizing Enzymes inAssociation with Risk of Bile Duct Cancer
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Cholangiocarcinoma (CCA) is the most common cancer in endemic areas of liver fluke infection. Althoughthe liver fluke is recognized as a carcinogenic agent in cholangiocarcinogenesis, other factors may play importantroles ...
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Systemic Therapy for Locally Advanced and Metastatic Cholangiocarcinoma
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)Cholangiocarcinoma, the typical bile duct epithelium neoplasm, is most commonly reported in the Northeast ofThailand. Surgical intervention is the only possible curative treatment in the early stage of disease. Unfortunately,most ...
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Autoimmunity and Cancer
(West Asia Organization for Cancer Prevention (WAOCP), 2012-12-01)The association between autoimmune diseases and cancer is to be considered one of the most well establishedand clinically challenging issues. Several mechanisms are shared in the pathogenesis of both autoimmune diseasesand ...
