• The First Global Report of Vindolinine in Vinca herbacea From the Hyrcanian Floristic Region: GC–MS Identification and Potential Anticancer Relevance 

  Kordkatouli, Mohammad؛ Mahmood Janlou, Mehr Ali؛ Varasteh Moradi, Ali؛ Rizwan, Muhammad؛ Sateei, Aryan؛ Javidi, Mohammad (Shahed University, 2025-01-01)

  Background: Vinca herbacea Waldst. & Kit. is a relatively understudied species of the Apocynaceae family, distributed across temperate regions of Asia and Europe, with verified populations in northern Iran, particularly ...

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• An Index to Assess Integrative Health Status in Human Studies 

  Vaez-Mahdavi, Mohammad-Reza؛ Nasiri, Leila (Shahed University, 2025-01-01)

  Background: Conventional metrics for assessing biological aging, like allostatic load or telomere length, have limitations in providing a comprehensive picture, especially across diverse populations exposed to chronic ...

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• Potential Mechanisms Linking SARS-CoV-2 to Autoimmunity 

  Ghazanfar, Tooba (Shahed University, 2025-01-01)

  Viral infections such as COVID-19 are significant environmental triggers for autoimmune diseases [1]. After infection with COVID-19, many autoimmune disorders that can potentially impact diverse organ systems may emerge ...

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• Effect of Melatonin on Interleukin-6 and Inflammatory Markers in Premature Infants With Documented Sepsis: A Pilot Study 

  Saeidi, Reza؛ Veysizadeh, Maryam؛ Nobakht, Elnaz؛ Alizadeh, Parinaz؛ Keshavarzi, Farnosh؛ Kordkatouli, Mohammad (Shahed University, 2025-03-01)

  Background: Premature neonates with documented sepsis who undergo surgery face heightened systemic inflammation, crucially mediated by interleukin-6 (IL-6). Given their low endogenous melatonin levels and melatonin's known ...

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• Effect of Melatonin on Immune System Enhancement and Pediatric Infections: A Systematic Review 

  Saeidi, Reza؛ Veysizadeh, Maryam؛ Kordkatouli, Mohammad (Shahed University, 2025-03-01)

  Background: Melatonin, a neurohormone primarily recognized for regulating circadian rhythm, also demonstrates immunomodulatory and anti-inflammatory properties. These effects suggest potential benefits in the management ...

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• Effects of Co-exposure to AhR Ligands and Lipopolysaccharides on RAW 264.7 Macrophage Polarization 

  Abbaszadeh, Parsa؛ Soudi, Sara؛ Shadboorestan, Amir (Shahed University, 2025-03-01)

  Background: Co-exposure to an aryl hydrocarbon receptor (AhR) agonist, such as benzo[a]pyrene (BaP) and lipopolysaccharides (LPS), commonly occurs through environmental pollution or smoking. The AhR plays a crucial role ...

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• Pyrimethamine Enhances the Immune Responses of RAW264.7 Macrophages Against Leishmania major 

  Azimzadeh Tabrizi, Zahra؛ Soudi, Sara؛ Zavaran Hosseini, Ahmad؛ Karimi, Mozhdeh (Shahed University, 2025-03-01)

  Background: Leishmania major, an intracellular protozoan, is the primary cause of cutaneous leishmaniasis (CL). Although polyvalent antimony compounds are commonly used to treat CL, treatment failure is frequent. Immunometabolic ...

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• GC-MS Analysis and Antibacterial Activity of Terminalia chebula Against β-lactam-resistant Kelebsiella pneumoniae 

  Koohsari, Hadi؛ Kordkatouli, Mohammad؛ Sateei, Aryan؛ Janlou, Mehr Ali Mahmood (Shahed University, 2025-03-01)

  Background: The increasing resistance of Klebsiella pneumoniae to β-lactam antibiotics poses a major challenge in treating hospital-acquired infections. Plant-derived compounds with antibacterial properties offer promising ...

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• Chronic Spontaneous Urticaria: Immune Dysregulation, Microbiome Imbalance, and Neuroinflammation 

  Shahabi, Haniyeh (Shahed University, 2025-03-01)

  Chronic spontaneous urticaria (CSU) is a complex dermatological disorder that affects both adults and children, with a higher prevalence among women, significantly impacting quality of life. Characterized by persistent ...

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• Morphine's Effects on the Gut-brain Axis, Inflammation, Behavior, and Microbiome Modulation in Rats 

  Ferdosnejad, Kianoosh؛ Zamani, Mohammad Saber؛ Rahimlou, Bahman؛ Tarashi, Samira (Shahed University, 2025-03-01)

  Background: The interaction between the gut microbiome and neurological outcomes is increasingly recognized, including in the context of opioid use and its immunomodulatory effects. This study investigates how morphine ...

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• A Therapeutic Hypothesis for Intrauterine Adhesions: Combining Mesenchymal Stem Cells With Pirfenidone 

  Rashidan, Kimiya؛ Ayadilord, Malaksima؛ Hashemi, Seyed Mahmoud (Shahed University, 2025-03-01)

  Intrauterine adhesions (IUAs), characterized by fibrous tissue bands within the endometrial cavity, present significant challenges to reproductive health. This condition leads to abnormal menstruation, infertility, and ...

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• Antitumor Potential of Vinca herbacea and Its Molecular Pathways in Inhibiting Cancer Cell Growth 

  Kordkatouli, Mohammad؛ Sateei, Aryan؛ Khoshbakht, Tayyebeh (Shahed University, 2025-03-01)

  Background: Vinca herbacea, a lesser-known member of the Apocynaceae family, has shown notable pharmacological effects, particularly in oncology. Its bioactive constituents—mainly vincristine, vinblastine, flavonoids, and ...

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• Chamomile Extracts Regulate IL-6 in PBMCs of Severe COVID-19 Patients 

  Rashidi, Rasoul؛ Mirsharif, Ensieh Sadat؛ Rashidi, Azadeh؛ Radjabian, Tayebeh؛ Ghazanfari, Tooba (Shahed University, 2025-03-01)

  Background: Matricaria chamomilla L. is advantageous due to its anti-inflammatory properties. The present study aimed to assess the efficacy of treating peripheral blood mononuclear cells (PBMCs) of COVID-19 patients with ...

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• Post COVID and Autoimmunity 

  Ghazanfari, Tooba (Shahed University, 2025-03-01)

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• Investigating Immunogenicity and Protectivity of Subcutaneous Administration of Salmonella Dublin Bacterin in Mice 

  Kazemi Moghaddam, Ehsan؛ Ghorbanpoor, Masoud؛ Mokhtari, Azam؛ Namavari, Mohammad Mehdi؛ Rasooli, Aria (Shahed University, 2025-03-01)

  Background: Given the significant zoonotic threat posed by Salmonella enterica serovar Dublin (S. Dublin) and its substantial impact on animal populations and public health, the objective of the present study was to assess ...

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• Eosinophilic Infiltration in Surgically Resected Gastrointestinal Tissue of Children With Non-traumatic Gastrointestinal Pathologies: A Descriptive Analysis 

  Eskandarzadeh, Shabnam؛ Darougar, Sepideh؛ Kazemi Aghdam, Maryam؛ Rouzrokh, Mohsen؛ Sohrabi, Mohammad-Reza؛ Sharifinejad, Niusha؛ Mansouri, Mahboubeh (Shahed University, 2025-03-01)

  Background: Considering that non-eosinophilic esophagitis eosinophilic gastrointestinal disorders (EGIDs) could mimic serious surgical conditions, including hypertrophic pyloric stenosis, intussusception, and bowel ...

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• Association Between Cardiac Telomere Length and Lipid Peroxidation in Pulmonary Hypertensive Chickens 

  Farhadi, Navid؛ Bahadoran, Shahab؛ Hassanpour, Hossein؛ Akbari, Mohammad-Reza (Shahed University, 2025-03-01)

  Background: Pulmonary hypertension syndrome (PHS) in broiler chickens is exacerbated by cold stress, leading to physiological responses that can adversely affect cardiac health. This study investigates the relationship ...

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• Antioxidant Effects of Marjoram (Origanum Majorana L.) Extract on Intestinal Morphology in Chickens With Pulmonary Hypertension 

  Bahadoran, Shahab؛ Teymouri, Younes؛ Hassanpour, Hossein؛ Mohebbi, Abdonnaser (Shahed University, 2025-03-01)

  Background: Marjoram is an herbal plant with different medicinal effects. This study evaluates its impact on enzymatic antioxidant status, growth performance, intestinal mucosa morphology, and pulmonary hypertensive response ...

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• The Therapeutic Effects of Mesenchymal Stem Cells Derived Extracellular Vesicles on Intrauterine Adhesions 

  پدیدآور نامشخص (Shahed University, 2025-03-01)

  Intrauterine adhesions (IUAs), also known as Asherman syndrome, is a pathological condition characterized by the development of fibrous scar tissue within the uterine cavity, leading to menstrual abnormalities, infertility, ...

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• Investigating Local Delivery of Mesenchymal Stromal Cell Extracellular Vesicles for Treatment-resistant Periodontitis: A Hypothesis 

  Farshadianpour, Koosha؛ Kiani, Kiarash؛ Saligheh Rad, Mona؛ Norooznezhad, Maryam (Shahed University, 2024-01-01)

  Background: One of the main reasons for tooth loss and functional incompatibility of dentition is periodontitis which is a multi-factorial disease. Among the main reasons for periodontitis is inflammation.Hypothesis: Some ...

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