Development of electrochemical sensor based on multiwall carbon nanotube for determination of anticancer drug idarubicin in biological samples

Abstract

A graphite paste electrode modified with Multiwall Carbon Nanotube (MWCNT) was prepared and used for low level determination of anticancer drug idarubicin (IDA) in biological fluids. The measurement was made using differential pulse voltammetry (DPV). The influence of some experimental variables such as composition of carbon paste, pH of solution, scan rate and possible interferences were studied. The charge transfer property of the fabricated composite electrode was characterized by electrochemical impedance spectroscopy (EIS). Furthermore, the morphology of the electrode was characterized by scanning electron microscopy (SEM). Under optimum conditions, the proposed sensor provides two linear DPV responses toeard IDA over the concentration ranges of 1–100 nM and 100–1000 nM for with a detection limit of 0.2 nM. Finally, the constructed sensor was successfully applied for determination of IDA in human urine and serum samples.